Frakefamide
CAS No. : 188196-22-7
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| Cat. No. : | HY-106147 |
| M.Wt: | 563.62 |
| Formula: | C30H34FN5O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Frakefamide is a potent analgesic that acts as a peripheral active μ-selective receptor agonist. Frakefamide is unable to penetrate the blood-brain-barrier and enter the central nervous system[1][2]. In Vivo: Frakefamide (LEF576) yields a dose dependent increase in morphine appropriate responding to 50% at the highest dose tested (10 μmol/kg) after infusion durations of 2 min, whereas after 15 min infusions a maximum of 25% morphine appropriate responding was occasioned at 17.5 μmol/kg[1][2].
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