Corynoline
CAS No. : 18797-79-0
Price and Availability of
CAS No. : 18797-79-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $100 | In-stock |
| 20mg | $180 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
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| Cat. No. : | HY-N0826 |
| M.Wt: | 367.40 |
| Formula: | C21H21NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 40 mg/mL (ultrasonic) |
Introduction of
18797-79-0
:
Corynoline is an orally active acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM. Corynoline exhibits multiple activities including anti-inflammatory, antinociceptive, antitumor and analgesic effects. Corynoline can be used in the research of diseases such as tumors and inflammatory pain[1][2][3][4].
In Vitro:Corynoline (1-4 μM; 24 h) inhibits LPS (HY-D1056)-induced NO production in RAW264.7 cells, upregulates the levels of Nrf2, HO-1 and NQO1, and downregulates the expression of iNOS and COX-2[1].
Corynoline (1-4 μM; 24 h) downregulates LPS-induced IL-1β and TNF-α expression at both mRNA and protein levels in RAW264.7 cells in a dose-dependent manner[1].
Corynoline (1 μM; 24 h) inhibits LPS-induced phosphorylation of p38 and JNK in RAW264.7 cells[1].
Corynoline (5-40 μM; 24-48 h) inhibits the proliferation and induces apoptosis of U87 and LN229 glioblastoma cells[2].
Corynoline (10-20 μM; 10-14 days) inhibits the colony-forming ability of U87 glioblastoma cells[2]. In Vivo:Corynoline (50 mg/kg; i.p.; 21 days) exerts antitumor activity in mouse models of glioblastoma[2].
Corynoline (5-20 mg/kg; oral administration; single dose) exerts a significant dose-dependent antinociceptive and anti-inflammatory effect in various nociceptive and inflammatory models of male mice[3].
Corynoline (1-4 μM; 24 h) downregulates LPS-induced IL-1β and TNF-α expression at both mRNA and protein levels in RAW264.7 cells in a dose-dependent manner[1].
Corynoline (1 μM; 24 h) inhibits LPS-induced phosphorylation of p38 and JNK in RAW264.7 cells[1].
Corynoline (5-40 μM; 24-48 h) inhibits the proliferation and induces apoptosis of U87 and LN229 glioblastoma cells[2].
Corynoline (10-20 μM; 10-14 days) inhibits the colony-forming ability of U87 glioblastoma cells[2]. In Vivo:Corynoline (50 mg/kg; i.p.; 21 days) exerts antitumor activity in mouse models of glioblastoma[2].
Corynoline (5-20 mg/kg; oral administration; single dose) exerts a significant dose-dependent antinociceptive and anti-inflammatory effect in various nociceptive and inflammatory models of male mice[3].
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