1α-Hydroxyvitamin D5
CAS No. : 187935-17-7
(Synonyms: CARD-024)
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| Cat. No. : | HY-13692 |
| M.Wt: | 428.69 |
| Formula: | C29H48O2 |
| Purity: | >98 % |
| Solubility: |
1α-Hydroxyvitamin D5 (CARD-024) is a vitamin D analog with extremely low hypercalcemic effects. 1α-Hydroxyvitamin D5 effectively attenuates the pro-fibrotic response of colonic myofibroblasts to TGFβ and high-stiffness substrates by inhibiting the expression of αSMA, the phosphorylation of FAK, and the gene expression of MLCK and ET-1, while activating the anti-inflammatory pathway of IL-1β/COX-2. 1α-Hydroxyvitamin D5 can be used in research related to intestinal fibrosis associated with Crohn's disease[1].
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