Rimeporide hydrochloride
CAS No. : 187870-95-7
(Synonyms: EMD-87580 hydrochloride)
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| Cat. No. : | HY-19273A |
| M.Wt: | 369.84 |
| Formula: | C11H16ClN3O5S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Rimeporide hydrochloride (EMD-87580 hydrochloride) is a potent and selective inhibitor of the Na+/H+ exchanger (NHE-1). IC50 & Target:NHE1[1] In Vitro: Blocking NHE-1 activity has been shown to decrease intracellular Na+ and Ca2+ overload and pH and Rimeporide (EMD-87580) represents a new therapeutic option for duchenne muscular dystrophy (DMD). Rimeporide (EMD-87580) is expected to act as a muscle-sparing agent and its mode of action means that it is mutation independent[1].
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