Carboxyamidotriazole (Orotate)
CAS No. : 187739-60-2
(Synonyms: L-651582 (Orotate); CAI (Orotate))
| Size | Price | Stock |
|---|---|---|
| 5mg | $160 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $410 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $810 | In-stock |
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| Cat. No. : | HY-16125 |
| M.Wt: | 580.76 |
| Formula: | C22H16Cl3N7O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 5 mg/mL (ultrasonic) |
Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects[1][2].
In Vitro: Carboxyamidotriazole Orotate (0.1-10 µM; 24-96 hours) inhibits cell proliferation of LAMA84R and K562R cell lines[1].
Carboxyamidotriazole Orotate inhibits the phosphorylation of a selected target of Bcr-Abl kinase. Tyrosine phosphorylation of CrkL is reduced by 5 µM Carboxyamidotriazole Orotate treatment[1].
In Vivo: Carboxyamidotriazole Orotate (342, 513 mg/kg; i.p.; Q1D×5 for two rounds) displays antitumor activity on CML xenografts[1].
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