PNU-142633
CAS No. : 187665-65-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $165 | In-stock |
| 5mg | $410 | Get quote |
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| 50 mg | Get quote | |
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| Cat. No. : | HY-103131 |
| M.Wt: | 422.52 |
| Formula: | C24H30N4O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 42 mg/mL (ultrasonic;warming) |
PNU-142633 is a high affinity, selective and orally active 5-HT1D receptor agonist with Kis of 6 nM and > 18 000 nM for human 5-HT1D receptor and human 5-HT1B receptor, respectively. PNU-142633 has anti-migraine efficacy[1][2]. In Vitro: The intrinsic activity of PNU-142633 at the human 5-HT1D receptor is determined to be 70% that of 5-HT in a cytosensor cell-based assay compared with 84% for that of Sumatriptan[1]. In Vivo: PNU-142633 (0.03-1 mg/kg; intravenous injection; male Hartley guinea pigs) treatment blocks neurogenic plasma protein extravasation. And PNU-142633 fails to alter resistance in these vascular beds[1].
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