DD1
CAS No. : 187585-11-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $175 | In-stock |
| 10mg | $297 | In-stock |
| 25mg | $468 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-120035 |
| M.Wt: | 282.29 |
| Formula: | C16H14N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner.?DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1].
In Vitro: DD1 (20 μM; 96 h) shows antiproliferation activity in a dose- and time-dependent manner in U937 cells[1].
DD1 induces cell cycle arrest at G2/M phase and apoptosis[1].
DD1 (10, 20 μM; 48 h) induces mitochondrial membrane depolarization, Bax upregulation and Bad dephosphorylation[1].
DD1 (2-20 μM; 40 h) shows inhibitor for chymotrypsin-like activity in U937 lysates[1].
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