BI8626
CAS No. : 1875036-75-1
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $350 | In-stock |
| 25mg | $620 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-120204 |
| M.Wt: | 440.54 |
| Formula: | C25H28N8 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
BI8626 is a specific inhibitor of the ubiquitin ligase HUWE1 with an IC50 of 0.9 μM[1].
IC50 & Target: IC50: 0.9 μM (HUWE1)[1]
In Vitro: BI8626 induces HUWE1 ectopically expresses to abolishe ubiquitination of MCL1 in HeLa cells[1].
BI8626 suppresses colony formation of Ls174T cells with estimated IC50 value of 0.7 μM, and BI8622 (1-4 days) treatment retards passage of Ls174T cells through all phases of the cell cycle, with the effect being strongest for G1[1].
BI8626 (0-50 μM; 0-6 hours) retards the degradation of MCL1 in response to UV irradiation to the same extent as depletion of HUWE1 in U2OS cells[1].
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