ER 50891
CAS No. : 187400-85-7
| Size | Price | Stock |
|---|---|---|
| 1mg | $200 | In-stock |
| 5mg | $530 | In-stock |
| 10 mg | Get quote | |
| 50 mg | Get quote | |
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| Cat. No. : | HY-108531 |
| M.Wt: | 432.51 |
| Formula: | C29H24N2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ER 50891 is a RARα antagonist. ER 50891 can significantly antagonize the inhibitory effect of all-trans retinoic acid (ATRA) on the total cell metabolic activity and proliferation of MC3T3-E1 preosteoblasts. ER 50891 rescues ATRA-inhibited osteocalcin (OCN) expression and extracellular matrix mineralization, and suppresses alkaline phosphatase (ALP) activity synergistically. ER 50891 can be used for the study of osteoporosis related to ATRA-induced inhibition of osteoblastogenesis[1].
IC50 & Target:RARα[1]
In Vitro:ER 50891 (1-3 μM, 3 days) significantly promotes total cell metabolic activity of MC3T3-E1 preosteoblasts alone and antagonizes the inhibitory effect of ATRA on total cell metabolic activity[1].
ER 50891 (0.25-3 μM, 3 days) dose-dependently relieves the inhibition of 1 μM ATRA on OCN expression in MC3T3-E1 preosteoblasts[1].
ER 50891 (1.5-3 μM, 19 days) rescues the extracellular matrix mineralization of MC3T3-E1 preosteoblasts inhibited by ATRA[1].
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