Psicofuranine
CAS No. : 1874-54-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $260 | In-stock |
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| Cat. No. : | HY-119819 |
| M.Wt: | 297.27 |
| Formula: | C11H15N5O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming) |
Psicofuramine a nucleoside antibiotic and has the inhibition of xanthosine 5'-phosphate aminase. Psicofuranine also specifically inhibits GMP synthase, and interrupts parasite growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth[1][2].
IC50 & Target: Xanthosine 5'-phosphate aminase[2]
P. falciparum[1]
E. coli[1]
In Vitro: Psicofuranine specifically inhibits bacterial GMP synthase as demonstrated by isolation of Psicofuranine-resistant Escherichia coli mutants with mutations in the gene encoding GMP synthase and inhibition of bacterial growth. Psicofuranine exhibits a dose-dependent inhibition of P. falciparum growth with an IC50 of 0.3 mM. The Psicofuranine inhibitory concentration is similar to that of E. coli[1].
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