NS309
CAS No. : 18711-16-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $66 | In-stock |
| 10mg | $79 | In-stock |
| 25mg | $160 | In-stock |
| 50mg | $277 | In-stock |
| 100mg | $440 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-15416 |
| M.Wt: | 231.04 |
| Formula: | C8H4Cl2N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
NS309 is a potent and selective activator of the Ca2+-activated SK/IK potassium channels, but displays no activity at BK channels[1][2][3][4].
IC50 & Target:EC50: 0.62 μM (SK2)[1], 0.3 μM (SK3)[2], ～20 nM (KCa3.1/SK4)[3], ～600 nM (KCa2/SK channels)[3], 10 nM (hIK)[4]
In Vitro: NS309 (40 nM) activates both hSK3 and hIK channels, with the largest effect on hIK channels (8.5-fold increase in current compares to 1.9-fold increase in current for hSK3 channels)[2].
NS309 (10 μM) significantly increases the whole cell SK currents and hyperpolarized detrusor smooth muscle (DSM) cells resting membrane potential[5].
NS309 inhibits the spontaneous phasic contraction amplitude, force, frequency, duration and tone of isolated DSM strips in a concentration-dependent manner[5].
In Vivo: NS309 (2 mg/kg; i.p.) protects against SCI/R in rabbits[6].
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