CFL-120
CAS No. : 18711-15-4
| Size | Price | Stock |
|---|---|---|
| 5g | $25 | In-stock |
| 10g | $41 | In-stock |
| 25g | $85 | In-stock |
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| Cat. No. : | HY-W041315 |
| M.Wt: | 216.02 |
| Formula: | C8H3Cl2NO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CFL-120 is a potent KRasG12C inhibitor. CFL-120 shows an antiproliferative effect. CFL-120 shows anticancer activity. CFL-120 has the potential for the research of lung cancer[1].
In Vitro:CFL-120 (72 h) shows an antiproliferative effect with IC50s of 11.0, 23.6, 13.7, 16.9, 44.4, 14.8, 38.0, 30.0, 13.1, 9.8, 47.9, 24.4, 42.7 µM for H1792, SW1573, MiaPaca2, H358, A549, SW480, PANC-1, LCLC-103H, BxPC3, HCA-7, MRC-5, HUVEC-TERT, CCD-986Sk cells, respectively[1].
In Vivo:CFL-120 (5 mg/kg, 5 treatments; 15 mg/kg, 5 treatments; 30 mg/kg, 3 treatments; i.p.) reduces tumor growth in subcutaneous H1792 (KRasG12C mutant) and LCLC-103H (KRasWT) human lung cancer-bearing mice[1].
Pharmacokinetic Parameters of CFL-120 in NOD-SCID female mice[1].
| PK parameters | CFL-137 |
| Cmax (ng/mL) | 337 ± 123 |
| Tmax (h) | 0.25 |
| AUCt (ng/mL*h) | 169 ± 56 |
| t1/2 (h) | 4.4 ± 0.6 |
| Vd (mL) | 12,096 ± 4000 |
| CL(mL/h) | 1895 ± 539 |
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