GyrB-IN-1
CAS No. : 1870007-38-7
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| Cat. No. : | HY-116783 |
| M.Wt: | 405.86 |
| Formula: | C21H12ClN3O2S |
| Purity: | >98 % |
| Solubility: |
GyrB-IN-1 is a DNA gyrase (GyrB) inhibitor. GyrB-IN-1 shows an IC50 of 19.1 μM against Mycobacterium smegmatis GyrB ATPase activity and 21.9 μM against Mycobacterium tuberculosis GyrB DNA supercoiling activity. GyrB-IN-1 exerts antimycobacterial activity and has cytotoxicity. GyrB-IN-1 can be used for the research of tuberculosis[1].
In Vitro:GyrB-IN-1 (Compound 13) inhibits M. smegmatis GyrB ATPase activity with an IC50 of 19.1 ± 1.8 μM[1].
GyrB-IN-1 inhibits M. tuberculosis GyrB-mediated DNA supercoiling activity with an IC50 of 21.9 ± 4.2 μM[1].
GyrB-IN-1 inhibits the growth of M. tuberculosis H37Rv strain with an MIC of 30.8 μM[1].
GyrB-IN-1 (100 μM) induces 22.35% cytotoxicity in RAW 264.7 cells[1].
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