A-893
CAS No. : 1868232-32-9
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| Cat. No. : | HY-19563 |
| M.Wt: | 577.54 |
| Formula: | C29H38Cl2N4O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
A-893 is a cell-active inhibitor of Methyltransferase SMYD2, with an IC50 of 2.8 nM. IC50 & Target: IC50: 2.8 nM (SMYD2)[1]. In Vitro: The ratio of p53K370me1 to overall p53 levels is reduced, as expected, by treatment with either A-893 or AZ505. While this unexpectedly depicts a more robust response with AZ505, further dissection of the data provides clarity into the origin of this. While overall p53 levels are unaffected by A-893, a surprising >3-fold increase is observed with AZ505. Analysis of p53K370me1 levels reveals that inhibitor A-893 exhibited 42% reduction in the methyl mark, while AZ-505 is slightly less effective at 28% reduction[1].
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