4-Methylcinnamic acid

4-Methylcinnamic acid is a cinnamic acid derivative with antifungal activity. 4-Methylcinnamic acid can overcome the tolerance of glutathione reductase mutants to 4-Methoxycinnamic acid (HY-N1387). When 4-Methylcinnamic acid is used in combination with traditional antifungal agents, it can reduce their minimum inhibitory concentrations. 4-Methylcinnamic acid can act as an intervention catalyst to enhance the efficacy of traditional antifungal agents and has application potential in targeting fungal cell wall disruption and controlling drug-resistant fungi^[1]. In Vitro:4-Methylcinnamic acid (0.5 mM; 5-7 days) exhibits growth inhibition against Saccharomyces cerevisiae cell wall integrity mutants slt2∆ and bck1∆, and also inhibits the growth of wild-type yeast^[1].
4-Methylcinnamic acid (0.5 mM; 5-7 days) completely inhibits growth in Saccharomyces cerevisiae glutathione reductase mutant glr1∆, overcoming its tolerance to 4-Methoxycinnamic acid (HY-N1387)^[1].
4-Methylcinnamic acid (0.1-6.4 mM; 48 hours) reduces the minimum inhibitory concentration and exhibits a chemosensitizing effect when used in combination with Caspofungin (HY-17006A) or Octyl gallate (HY-N2011) in Aspergillus brasiliensis^[1].