DU-14
CAS No. : 186303-55-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $150 | In-stock |
| 10mg | $256 | In-stock |
| 25mg | $510 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-116377 |
| M.Wt: | 426.61 |
| Formula: | C22H38N2O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
DU-14 is a potent steroid sulfatase inhibitor with an IC50 of 55.8 nM. DU-14 inhibits the MCF-7 cell proliferation (IC50 = 38.7 nM). DU-14 has neuroprotective effects against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity[1][2][3].
In Vitro:DU-14 (0.001-10 μM, 18 h) inhibits estrone sulfatase activity in MDA-MB-23l cell, with an IC50 of 350 nM[1].
In Vivo:DU-14 (30 mg/kg, i.p., once time) inhibits steroid sulfatase activity in both brain and liver tissues and enhances the memory-enhancing properties of DHEAS in rats with scopolamine-induced amnesia[2].
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