ABT-255 (free base)
CAS No. : 186293-38-9
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| Cat. No. : | HY-113619 |
| M.Wt: | 385.43 |
| Formula: | C21H24FN3O3 |
| Purity: | >98 % |
| Solubility: |
ABT-255 free base is an orally active anti-bacterial agent. ABT-255 free base exhibits potent in vitro potency (MIC = 0.016-0.031 μg/mL) against drug-susceptible and Rifampin (HY-B0272)- or Ethambutol (HY-B0535)-resistant Mycobacterium tuberculosis. ABT-255 free base shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice. ABT-255 free base can be used for the study of pulmonary tuberculosis[1].
In Vitro:ABT-255 (0.016-0.5 μg/mL) free base shows MIC values of 0.016 μg/mL against ATCC 35801, 0.031 μg/mL against ATCC 25618, and 0.031 μg/mL against both 35837b (Ethambutol (HY-B0535)-resistant) and 35838c (Rifampin (HY-B0272)-resistant)[1].
In Vivo:ABT-255 (3.13-25 mg/kg, p.o., once daily, 4 weeks) free base shows efficacy against S. aureus, S. pneumoniae and E. coli and reduces viable counts of drug-resistant Mycobacterium tuberculosis in CF-1 mice[1].
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