Lurasidone metabolite 14326
CAS No. : 186204-33-1
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| Cat. No. : | HY-G0002 |
| M.Wt: | 508.68 |
| Formula: | C28H36N4O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Lurasidone metabolite 14326 is a minor active metabolite of Lurasidone (HY-B0032A) generated via metabolism by CYP3A4. Lurasidone metabolite 14326 shares similar receptor-binding properties with Lurasidone, acting as an antagonist of the dopamine D2 receptor (dopamine D2 receptor), an antagonist of the serotonin 5-HT2A and 5-HT7 receptors (5-HT2A and 5-HT7 receptor), and a partial agonist of the serotonin 5-HT1A receptor. Lurasidone metabolite 14326 can be used in the research of schizophrenia and bipolar depression[1]. In Vitro:Lurasidone metabolite 14326 exhibits receptor-binding pharmacodynamic activity similar to that of Lurasidone in assays using rat, guinea pig and human recombinant cell receptors, but its exposure (concentration) in humans is extremely low[1].
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