BMS-199264 (hydrochloride)
CAS No. : 186180-83-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $340 | In-stock |
| 10mg | $540 | In-stock |
| 25mg | $1080 | In-stock |
| 50mg | $1750 | In-stock |
| 100mg | $2800 | In-stock |
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| Cat. No. : | HY-118960 |
| M.Wt: | 567.53 |
| Formula: | C26H32Cl2N4O4S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
BMS-199264 hydrochloride is an inhibitor of F1F0 ATP hydrolase (IC50=0.5 μM) without inhibitory effect on F1F0 ATP synthase. BMS-199264 hydrochloride selectively inhibits ATP decline during ischemia to reduces cardiac necrosis. BMS-199264 hydrochloride also enhances the recovery of contractile function following reperfusion[1].
In Vitro:BMS-199264 hydrochloride (1 μM, 3 μM, 10 μM) increases the time to onset of contracture and decreases LDH release, in a concentration-dependent manner in isolated rat hearts after a 25-min global ischemia followed by a 30-min reperfusion[1].
BMS-199264 hydrochloride (3 μM) shows different effects on ATP synthase or hydrolase activity with values of 0.23 μM ATP/min/mg and 0.18 μM ATP/min/mg, respecctively[1].
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