Cilobradine (hydrochloride)
CAS No. : 186097-54-1
(Synonyms: DK-AH 269)
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|---|---|---|
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| 10mg | $160 | In-stock |
| 25mg | $320 | In-stock |
| 50mg | $512 | In-stock |
| 100mg | $820 | In-stock |
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| Cat. No. : | HY-18940A |
| M.Wt: | 519.07 |
| Formula: | C28H39ClN2O5 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : ≥ 125 mg/mL |
Cilobradine hydrochloride is a HCN channel blocker. Cilobradine hydrochloride induces cardiac pacemaker currents and produces antidepressant effects[1][2][3][4][5].
In Vitro:Cilobradine (1 μM) hydrochloride induces a use-dependent blockade of cardiac pacemaker current in rabbit sino-atrial cells[2].
Cilobradine blocks HCN channel currents in HEK293 cells expressing human HCN1, HCN2, HCN3, and HCN4 channels in a dose- and treatment-dependent manner, and its steady-state inhibition of different HCN isoforms is not isoform-specific[3].
In Vivo:Cilobradine (4-40 mg/kg; s.c,; single dose) hydrochloride can prolong the latency of the a-wave or b-wave of the rat electroretinogram (ERG), and a dose-dependent waveform change after the b-wave occurs at a specific light stimulus brightness[4].
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Cilobradine (intracerebroventricular injection dose 0.6 μg; intraperitoneal injection dose 20 mg/kg; intracerebroventricular microinjection and i.p.; single dose) hydrochloride can reverse depressive-like behavior, and the effect lasts for about two weeks[5].
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