CPUY201112
CAS No. : 1860793-58-3
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| Cat. No. : | HY-111524 |
| M.Wt: | 357.40 |
| Formula: | C19H23N3O4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CPUY201112 is a potent heat shock protein Hsp90 inhibitor with Kd of 27 nM. CPUY201112 induces p53-mediated apoptosis in MCF-7 cells, resulting in cell cycle arrest, which can be used in cancer research[1].
In Vitro:CPUY201112 (0-9 μM, 7 days) reduces the viability of multiple cancer cell lines such as HCT116 colon cells, HepG2 hepatocellular carcinoma and other cancer cells in a dose-dependent manner[1].
CPUY201112 (0-2 μM, 24 h) can induce apoptosis in a dose-dependent manner[1].
In Vivo:CPUY201112 (5-40 mg/kg, i.p., daily, 3 weeks) inhibits tumor growth in the MCF-7 tumor xenograft model[1].
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