Metreleptin
CAS No. : 186018-45-1
(Synonyms: r-metHuLeptin)
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| Cat. No. : | HY-108799 |
| M.Wt: | 1000.00 |
| Formula: | N/A |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Metreleptin (r-metHuLeptin) is a recombinant methionyl human leptin. Metreleptin binds to and activates the human leptin receptor, which belongs to the Class I cytokine family of receptors. Metreleptin activates Jak2 and STAT3 signaling pathways. Metreleptin alters bone remodeling milieu to favor bone accretion. Metreleptin can be used for the research of congenital leptin deficiency (CLD), lipodystrophy syndromes and obesity[1][2][3].
In Vitro: Metreleptin activates Jak2 and STAT3 signaling pathways in dose- and time-dependent manner in CM and USMC[1].
Metreleptin increases ERK1/2, JNK and/or p38 phosphorylation in CM[1].
Metreleptin increases cell size (hypertrophy) in both CM and USMC[1].
In Vivo: Metreleptin significantly increases bone mineral content (BMC) and tended to increase bone mineral density (BMD) at the lumbar spine[3].
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