Eritoran (tetrasodium)
CAS No. : 185954-98-7
(Synonyms: E5564)
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| Cat. No. : | HY-105070A |
| M.Wt: | 1401.58 |
| Formula: | C66H122N2Na4O19P2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Eritoran tetrasodium (E5564) is a Toll-like receptor 4 (TLR4) antagonist. Eritoran tetrasodium protects mice against lethal influenza virus infection, such as Ebola virus (EBOV), Marburg virus (MARV). Eritoran tetrasodium decreases the level of granulocytosis, may alleviate the severity of the "cytokine storm". Eritoran tetrasodium inhibits pathogenesis of filovirus infection. Eritoran tetrasodium has anti-inflammatory activity[1][2].
In Vivo:Eritoran tetrasodium (233 μg/mouse; i.p.; 10 days) protects mouse from EBOV lethal infection, results 70% survived until the end of the study[1].
Eritoran tetrasodium (2 μL of 1.1 mg/mL, corneal infusion) inhibits LPS (HY-D1056) -induced corneal inflammation in mice[2].
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