Propargyl-PEG2-acid
CAS No. : 1859379-85-3
| Size | Price | Stock |
|---|---|---|
| 1g | $29 | In-stock |
| 5g | $105 | In-stock |
| 25g | $524 | In-stock |
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| Cat. No. : | HY-118764 |
| M.Wt: | 172.18 |
| Formula: | C8H12O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Propargyl-PEG2-acid is a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-acid is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
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