Etoprine
CAS No. : 18588-57-3
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| Cat. No. : | HY-105714 |
| M.Wt: | 283.16 |
| Formula: | C12H12Cl2N4 |
| Purity: | >98 % |
| Solubility: |
Etoprine is a potent orally active dihydrofolate reductase (DHFR) inhibitor. Etoprine competitively inhibits testicular DHFR to disrupt tetrahydrofolate and DNA synthesis in rapidly dividing cells. Etoprine acts as an antifertility agent in male mice and reduces fecundity in male rats[1][2].
In Vitro:Etoprine (6 h) potently inhibits growth of E. coli BL21(DE3)pLysS expressing wild-type PvDHFR-TS with an IC50 of 0.07 μM[2].
Etoprine (6 h) moderately inhibits growth of E. coli BL21(DE3)pLysS expressing SP21 mutant PvDHFR-TS with an IC50 of 10.45 μM[2].
In Vivo:Etoprine (0.1-50 mg/kg; p.o.; daily; 55 days) acts as a potent male antifertility agent in mice[1].
Etoprine (5 mg/kg/day; p.o.; daily; 65 days) reduces male rat fecundity via spermatogenesis inhibition[1].
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