OGT-719
CAS No. : 185843-61-2
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| Cat. No. : | HY-19272 |
| M.Wt: | 292.22 |
| Formula: | C10H13FN2O7 |
| Purity: | >98 % |
| Solubility: |
OGT-719 is a potent, orally active nucleoside analogue that targets the asialoglycoprotein receptor (ASGP-R). OGT-719 inhibits growth of metastatic colorectal tumors in the liver of nude mice. OGT-719 can be used for primary hepatocellular carcinoma and colorectal liver metastases research[1]. In Vitro:OGT-719 (80 mM, 4 h) inhibits thymidylate synthase (TS) activity in C170HM2 cells at a concentration of 80 mM (approximately 2xIC50)[1]. In Vivo:OGT-719 (1500 mg/kg/day, p.o., b.i.d. for 32 days) significantly inhibits growth of metastatic colorectal tumors in the liver of nude mice[1].
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