TAK-828F
CAS No. : 1854901-94-2
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| Cat. No. : | HY-111509 |
| M.Wt: | 509.57 |
| Formula: | C28H32FN3O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
TAK-828F is a potent, selective, and orally available retinoic acid receptor-related orphan receptor γt (RORγt) inverse agonist (binding IC50=1.9 nM, reporter gene IC50=6.1 nM). TAK-828F shows excellent RORγt isoforms selectivity (>5000-fold selectivity against human RORα and RORβ)[1]. IC50 & Target: IC50: 1.9 nM (RORγt, binding IC50), 6.1 nM (RORγt, reporter gene IC50)[1] In Vivo: TAK-828F (0.3, 1, and 3 mg/kg; orally administered; b.i.d.; 28 days; in mice with IL-23-induced cytokine expression model) shows robust and dose-dependent inhibition of IL-17A expression with an ED80 of 0.5 mg/kg[1].
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