2-Deoxy-L-ribose
CAS No. : 18546-37-7
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| Cat. No. : | HY-W012670 |
| M.Wt: | 134.13 |
| Formula: | C5H10O4 |
| Purity: | >98 % |
| Solubility: |
2-Deoxy-L-ribose is a stereoisomer of 2-Deoxy-d-ribose that inhibits 2-Deoxy-d-ribose anti-apoptotic effects. 2-Deoxy-L-ribose suppresses metastasis of tumor cells overexpressing thymidine phosphorylase[1].
In Vitro:2-Deoxy-L-ribose (10-100 μM; 24 h) significantly reduces the number of invading KB/TP cells under hypoxia[1].
2-Deoxy-L-ribose (10-100 μM; 48 h) decreases VEGF and IL-8 mRNA levels in KB/TP cells under hypoxia[1].
In Vivo:2-Deoxy-L-ribose (20-100 mg/kg; p.o.; daily; 28 days) reduces liver metastatic nodules and metastatic area, suppresses angiogenesis, and enhances apoptosis[1].
2-Deoxy-L-ribose (20 mg/kg; p.o.; daily; 52 days) showes superior efficacy to Tegafur (HY-17400) (100 mg/kg) in reducing abdominal metastatic nodules[1].
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