RS-102221
CAS No. : 185376-97-0
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| Cat. No. : | HY-101365 |
| M.Wt: | 612.62 |
| Formula: | C27H31F3N4O7S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
RS-102221 is a selective 5-HT2C receptor antagonist (Ki=10 nM). RS-102221 shows nearly 100-fold selectivity for the 5-HT2C receptor as compared to the 5-HT2A and 5-HT2B receptors. RS-102221 can promote the differentiation of new nerve cells. RS-102221 increases food-intake and weight-gain in rats[1][2].
In Vitro:RS-102221 (0.3-300nM; 24 h) promotes the differentiation of adult hippocampal neural precursor cells (ahNPCs) and significantly increases the percentage of MAP-2+ cells[1].
In Vivo:RS-102221 (2 mg/kg; i.p.; once daily for 14 d) increases food-intake and weight-gain in rats[2].
RS-102221 (2 mg/kg; i.p.; single dose), combined with the 3,4-Methylenedioxy-N-methamphetamine (MDMA or 'ecstasy'), suppresses the MDMA-induced hypophagia for the first 1 h period, and also suppresses MDMA-induced hyperlocomotion in mice[3].
RS-102221 (2 mg/kg; i.p.; single dose) can reduce anxiety and reduce the amplitude of startle reflex in mice in light and dark test[4].
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