NQTrp
CAS No. : 185351-19-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $45 | In-stock |
| 5mg | $90 | In-stock |
| 10mg | $139 | In-stock |
| 25mg | $315 | In-stock |
| 50mg | $472 | In-stock |
| 100mg | $708 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-19738 |
| M.Wt: | 360.36 |
| Formula: | C21H16N2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic;warming;heat to 60°C) |
NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin[1]. In Vitro: In TEM analysis, GDC6 peptide fibrils (50 μM) in the presence of NQTrp 5:1, 1:1, 1:5 ratio (GDC6: NQTrp). NQTrp effectively inhibits the fibrillation of the GDC6 peptide (50 μM) in a dose-dependent manner and prevents the formation of elongated amyloid fibrils[1].NQTrp has no toxic effect toward retinal cell culture and reduces the cytotoxicity induced by aggregates of the hexapeptide(IC50=70 μM) in ARPE-19 cells[1].
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