PF-739
CAS No. : 1852452-14-2
| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | In-stock |
| 10mg | $425 | In-stock |
| 25mg | $893 | In-stock |
| 50mg | $1518 | In-stock |
| 100mg | $2580 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-117755 |
| M.Wt: | 442.89 |
| Formula: | C23H23ClN2O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
PF-739 is an orally active and non-selective activator of AMPK. PF-739 activates 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes[1][2].
In Vitro:PF-739 activates α2β1γ1, α2β2γ1, α1β1γ1 and α1β2γ1 with EC50 values of 5.23 nM, 42.2 nM, 8.99 nM and 126 nM, respectively[1].
PF-739 (0-1000 nM) increases the phosphorylation of AMPK substrate in primary rat hepatocytes and myotubes of primary human cardiac cell line with dose-dependent manner[2].
In Vivo:PF-739 (30-1000 mg/kg; p.o. or s.c.; single does) effectively activates AMPK in liver cells and skeletal muscle and reduces plasma glucose level in C57BL/6 mice[2].
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