Acotiamide
CAS No. : 185106-16-5
(Synonyms: Z-338 (free base); YM443 (free base))
| Size | Price | Stock |
|---|---|---|
| 10mg | $25 | In-stock |
| 25mg | $42 | In-stock |
| 50mg | $60 | In-stock |
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| Cat. No. : | HY-121467 |
| M.Wt: | 450.55 |
| Formula: | C21H30N4O5S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Acotiamide is an orally active, selective and reversible acetylcholinesterase (AChE) inhibitor, with an IC50 of 1.79 μM. Acotiamide can enhance gastric contractility and accelerate delayed gastric emptying. Acotiamide has the potential for the research of functional dyspepsia involving gastric motility dysfunction and intestinal inflammatory[1][2][3].
IC50 & Target:IC50: 1.79 μM (AChE)[3].
In Vitro:Acotiamide (10, 30, 100 μM; 1 hour) reduces expression levels of IκB-α phosphorylation in LPS- and MCP-1-stimulated macrophage cell lines[1].
In Vivo:Acotiamide (0.3, 1, 3 mg/kg; i.v./3, 10, 30 mg/kg; p.o.) increases the postprandial gastric motility index in a dose-dependent manner[2].
Acotiamide (0.83 mg/kg; i.v.; once) inhibits AChE in rat stomach with an IC50 value of 1.79 μM[3].
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