PD0166285
CAS No. : 185039-89-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $165 | In-stock |
| 10mg | $264 | In-stock |
| 25mg | $530 | In-stock |
| 50mg | $810 | In-stock |
| 100mg | $1160 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-13925 |
| M.Wt: | 512.43 |
| Formula: | C26H27Cl2N5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
PD0166285, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 exhibits an IC50 of 3.433 μM for Chk1[1].
IC50 & Target: IC50: 24 nM (WEE1), 72 nM (Myt1), 3.433 μM (Chk1)[1].
In Vitro: PD0166285 (0.5 μM) dramatically inhibits irradiation-induced Cdc2 phosphorylation at the Tyr-15 and Thr-14 in seven of seven cancer cell lines[1].
PD0166285 sensitizes radiation-induced cell killing in p53 mutant HT29 cells and in the E6-transfected, p53-null ovarian cancer cell line PA-1 but to a lesser extent in p53 wild-type PA-1 cells. PD0166285 abrogates irradiation-induced G2 arrest and significantly increases mitotic cell populations[1].
PD0166285 acts as a radiosensitizer to sensitize cells to radiation-induced cell death with a sensitivity enhancement ratio of 1.23[1].
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