Robalzotan (hydrochloride)
CAS No. : 184674-99-5
(Synonyms: NAD-299 (hydrochloride))
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| Cat. No. : | HY-10351A |
| M.Wt: | 354.85 |
| Formula: | C18H24ClFN2O2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Robalzotan hydrochloride (NAD-299 hydrochloride) is a potent and selective 5-Hydroxytryptamine 1A (5-HT1A) inhibitor. Robalzotan hydrochloride increases the firing rate of 5-HT cells. Robalzotan hydrochloride induces 5-HT1A receptor occupancy. Robalzotan hydrochloride has the potential for the research of a cholinergic deficit in the central -nervous system[1][2][3].
In Vivo:Robalzotan hydrochloride (1-100 µg/kg; i.v.) significantly increases the activity of such neurons at 5 µg/kg in rats, and reverses the acute inhibitory effect of citalopram (HY-121203) (300 µg/kg i.v.) or paroxetine (HY-122272) (100 µg/kg, i.v.) on the activity of 5-HT neurons in the dorsal raphe nucleus in rats[1].
Robalzotan hydrochloride (5, 50 µg/kg; i.v.) increases the firing rate of the 5-HT cells[1].
Robalzotan hydrochloride (2-100 µg/kg; i.v.) occupies 5-HT1A receptors in a dose-dependent in monkeys[2].
Robalzotan hydrochloride (0.3; 1 and 3 µmol/kg s.c) causes a dose-dependent increase of extracellular ACh levels in the rat FC[3].
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