CM-579
CAS No. : 1846570-40-8
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| Cat. No. : | HY-117421 |
| M.Wt: | 492.65 |
| Formula: | C29H40N4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells[1]. IC50 & Target: IC50: 16 nM (G9a), 32 nM (DNMT)[1]. In Vitro: The Kd of CM-579 for DNMT1 is 1.5 nM, CM-579 also inhibits DNMT3A and DNMT3B, with IC50s of 92 nM and 1000 nM, respectively[1].
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