Carabersat
CAS No. : 184653-84-7
(Synonyms: SB-204269)
| Size | Price | Stock |
|---|---|---|
| 5mg | $180 | In-stock |
| 10mg | $290 | In-stock |
| 25mg | $580 | In-stock |
| 50mg | $930 | In-stock |
| 100mg | $1490 | In-stock |
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| Cat. No. : | HY-U00307 |
| M.Wt: | 357.38 |
| Formula: | C20H20FNO4 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
Carabersat is a potent anticonvulsant agent. In Vitro: [3H]Carabersat ([3H]SB 204269) binds to rat forebrain membranes with moderate affinity (Kd 40 nM) and pKi values of 7.3[1]. Carabersat is able to bind to mouse forebrain membranes, and the binding is saturable and stereospecific, with a Kd of 53 nM. The labelled [3H]Carabersat produces a Kd of 32 nM[2]. Carabersat (SB-204269, 1-100 μM) has no effect on Na+ current in cultured hippocampal neurones. Carabersat also shows no effect on action potential discharges evoked by elevating external K+[3]. Carabersat (SB-204269) is structurally-related to the benzopyran ATP-sensitive potassium channel (KATP) opener, cromakalim, but has opposite stereochemistry, and the mechanism of action of Carabersat is not thought to involve KATP[4]. In Vivo: Carabersat (5b) significantly elevates anticonvulsant activity in mice[1].
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