ROS 234
CAS No. : 184576-87-2
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| Cat. No. : | HY-107563 |
| M.Wt: | 241.29 |
| Formula: | C13H15N5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ROS 234 is a potent H3 antagonist, with a pKB of 9.46 for Guinea-pig ileum H3-receptor, a pKi of 8.90 for Rat cerebral cortex H3-receptor, and a ED50 of 19.12 mg/kg (ip) in ex vivo of Rat cerebral cortex. ROS 234 diaplays poor central access[1][2].
IC50 & Target: pkB: 9.46 (Guinea-pig ileum H3-receptor)[1].
pKi: 8.90 (Rat cerebral cortex H3-receptor)[1].
ED50: 19.12 mg/kg (ip, in ex vivo of Rat cerebral cortex) [1].
In Vivo: ROS 234 centrally injected, significantly shortens pentobarbital narcosis[1].
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