Madecassic acid
CAS No. : 18449-41-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $55 | In-stock |
| 10mg | $88 | In-stock |
| 20mg | $154 | In-stock |
| 50mg | $277 | In-stock |
| 100mg | $416 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-N0569 |
| M.Wt: | 504.70 |
| Formula: | C30H48O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Madecassic acid is isolated from Centella asiatica (Umbelliferae). Madecassic acid has anti-inflammatory properties caused by iNOS, COX-2, TNF-alpha, IL-1beta, and IL-6 inhibition via the downregulation of NF-κB activation in RAW 264.7 macrophage cells[1].
In Vitro:Madecassic acid (150μM, 24 h) inhibits LPS (HY-D1056)-induced iNOS and COX-2 protein expression[1].
In Vivo:Madecassic acid (p.o, 25 mg/kg, 10 days) reduces the level of IL-17 and the number of γδT17 cells in colon tissues of colitis mice, and attenuates colitis in mice[2].
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