Gefitinib (GMP)


CAS No. : 184475-35-2

(Synonyms: ZD1839 (GMP))

184475-35-2
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Cat. No. : HY-50895G
M.Wt: 446.90
Formula: C22H24ClFN4O3
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 184475-35-2 :

Gefitinib (ZD1839) (GMP) is Gefitinib (HY-50895) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Gefitinib is a potent, selective and orally active EGFR tyrosine kinase inhibitor[1][2]. IC50 & Target:IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)[1]. In Vitro:Gefitinib (GMP) abolishes the effect of EGF-induced dedifferentiation of astrocytes into astrocyte precursor cells (APCs)[2].
Gefitinib (3 μM) can produce a subgroup of EGFR-mutant NSCLC cell lines (Gefitinib-resistant cells) that undergo cellular reprogramming, such as HCC827 cells[3].

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