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|---|---|---|
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| 500 mg | Get quote | |
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| Cat. No. : | HY-50895G |
| M.Wt: | 446.90 |
| Formula: | C22H24ClFN4O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Gefitinib (ZD1839) (GMP) is Gefitinib (HY-50895) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Gefitinib is a potent, selective and orally active EGFR tyrosine kinase inhibitor[1][2].
IC50 & Target:IC50: 37 nM (Tyr1173 site, in NR6wtEGFR cells), 37 nM (Tyr992 site, in NR6wtEGFR cells)[1].
In Vitro:Gefitinib (GMP) abolishes the effect of EGF-induced dedifferentiation of astrocytes into astrocyte precursor cells (APCs)[2].
Gefitinib (3 μM) can produce a subgroup of EGFR-mutant NSCLC cell lines (Gefitinib-resistant cells) that undergo cellular reprogramming, such as HCC827 cells[3].
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