CXCR2-IN-2
CAS No. : 1838123-21-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $400 | In-stock |
| 10mg | $680 | In-stock |
| 25mg | $1300 | In-stock |
| 50mg | $2100 | In-stock |
| 100mg | $3300 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-120878 |
| M.Wt: | 414.90 |
| Formula: | C18H23ClN2O5S |
| Purity: | >98 % |
| Solubility: | DMSO : 240 mg/mL (ultrasonic) |
CXCR2-IN-2 is a selective, brain penetrant, and orally bioavailable CXCR2 antagonist (IC50=5.2 nM/1 nM in β-arrestin assay/CXCR2 Tango assay, respectively). CXCR2-IN-2 displays ~730-fold selectivity over CXCR1 and >1900-fold selectivity over all other chemokine receptors. CXCR2-IN-2 inhibits human whole blood Gro-α induced CD11b expression with an IC50 of 0.04 μM[1]. In Vivo: CXCR2-IN-2 (compound 68) (1-10 mg/kg; p.o.; twice daily for 3 days) dose-dependently reduces neutrophil infiltration in vivo in rat and mouse air pouch models[1].
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- Cat. No.:
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