MRS1220
CAS No. : 183721-15-5
| Size | Price | Stock |
|---|---|---|
| 5mg | $200 | In-stock |
| 10mg | $320 | In-stock |
| 25mg | $576 | In-stock |
| 50mg | $835 | In-stock |
| 100mg | $1169 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-103190 |
| M.Wt: | 403.82 |
| Formula: | C21H14ClN5O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 4 mg/mL (ultrasonic;warming;heat to 60°C) |
MRS1220, a highly potent and selective human A3 adenosine receptor (hA3AR) antagonist with a Ki of 0.59 nM, has therapeutic potential for the research of diseases of the central nervous system[1]. MRS1220 reduces glioblastoma tumor size and blood vessel formation in vivo[2].
In Vitro:MRS 1220 reverses the effect of A3 agonist-elicited inhibition of tumor necrosis factor-α formation in the human macrophage U-937 cell line with an IC50 of 0.3 μM[1].
VEGF secretion in U87MG glioblastoma stem-like cells (GSCs) decreases ~25% with MRS1220 after 72 h of hypoxia[2].
In Vivo:MRS1220 (0.15 mg/kg; intraperitoneal inoculation) reduces tumor size and blood vessel formation in vivo. MRS1220 exhibits a strong in vivo anti-angiogenic effect[2].
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