AM404
CAS No. : 183718-77-6
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| Cat. No. : | HY-101388 |
| M.Wt: | 395.58 |
| Formula: | C26H37NO2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
AM404, an inhibitor of endocannabinoid reuptake, blocks anandamide transport with IC50 values in the low micromolar range[1]. AM404 is able to relax rat isolated hepatic arteries contracted with Phenylephrine, with a pEC50 value of 7.4 (corresponding to an EC50 of 0.04 μM). Neuroprotective Effect[2]. In Vitro: AM404 reduces C6 glioma cell proliferation with IC50 values of 4.9 μM. AM404 non-specifically inhibit C6 glioma cell proliferation at concentrations used to block the cellular accumulation of the endocannabinoid anandamide[2]. In Vivo: AM404 (1-5 mg/kg, i.p.) exerts dose-dependent anxiolytic-like effects in the three models: elevated plus maze, defensive withdrawal and separation-induced ultrasonic vocalizations.
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