CYN 154806
CAS No. : 183658-72-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $180 | In-stock |
| 5mg | $580 | In-stock |
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| Cat. No. : | HY-P1202 |
| M.Wt: | 1197.34 |
| Formula: | C56H68N12O14S2 |
| Purity: | >98 % |
| Solubility: | H2O : 12.5 mg/mL (ultrasonic) |
CYN 154806, a cyclic octapeptide, is a potent and selective somatostatin sst2 receptor antagonist, with pIC50 values of 8.58, 5.41, 6.07, 5.76 and 6.48 for human recombinant sst2, sst1, sst3, sst4 and sst5 receptors respectively[1][2]. IC50 & Target:Somatostatin Receptor[1]. In Vitro: CYN 154806 inhibits SRIF-induced increases in extracellular acidification (EAR) in CHO-K1 cells expressing human sst2 receptors (pKB 7.92). CYN 154806 also blocks SRIF-induced increases [35S]-GTPγS binding in CHO-K1 cell membranes expressing human sst2 receptors as well as rat sst2(a) and rat sst2(b) receptors (pKB 7.81, 7.68 and 7.96, respectively)[2]. In Vivo: CYN 154806 (0.1 mg/kg; i.p.; 20 min before the administration of carbachol (CCh) (30 μg/kg) in M4 KO mice) dose-dependently and significantly reverses the decreases acid response to CCh in M4 but not M3 KO mice[3].
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