CPI-1189
CAS No. : 183619-38-7
| Size | Price | Stock |
|---|---|---|
| 5mg | $50 | In-stock |
| 10mg | $80 | In-stock |
| 25mg | $170 | In-stock |
| 50mg | $280 | In-stock |
| 100mg | $460 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100376 |
| M.Wt: | 234.30 |
| Formula: | C13H18N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
CPI-1189 is an orally active TNF-α release inhibitor. CPI-1189 inhibits phosphorylation of p38. CPI-1189 can inhibit apoptosis. CPI-1189 can be used in the study of HIV and neurological diseases[1][2][3][4][5].
In Vitro:CPI-1189 (100 nM, 1 h) can effectively inhibit Oxygen glucose deprivation (OGD)/re-oxygenation (OGDR) induced oxidative damage and neuronal cell death in SH-SY5Y cells[3].
CPI-1189 (10 nM, 2 h) inhibits interleukin1β-induced phosphorylation of P38-mitogen-activated protein kinase[4].
In Vivo:CPI-1189 (20 mg/kg, p.o., twice a day) reversed memory deficits in a TNF-α-induced AIDS-dementia rat model[5].
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