(S,R,S)-AHPC-PEG2-C4-Cl
CAS No. : 1835705-57-1
(Synonyms: VH032-PEG2-C4-Cl; VHL Ligand-Linker Conjugates 7; E3 ligase Ligand-Linker Conjugates 10)
| Size | Price | Stock |
|---|---|---|
| 50mg | $344 | In-stock |
| 100mg | $550 | In-stock |
| 500mg | $1950 | In-stock |
| 1g | $3350 | In-stock |
| 2g | $4900 | In-stock |
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| Cat. No. : | HY-103607 |
| M.Wt: | 651.26 |
| Formula: | C32H47ClN4O6S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 50 mg/mL;Ethanol : 50 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
(S,R,S)-AHPC-PEG2-C4-Cl (VH032-PEG2-C4-Cl) is a conjugate of ligands for E3 and 13-atom-length linker. The connector of linker is Halogen group. (S,R,S)-AHPC-PEG2-C4-Cl incorporates the (S,R,S)-AHPC based VHL ligand and an alkyl/ether-based linker. (S,R,S)-AHPC-PEG2-C4-Cl is capable of inducing the degradation of GFP-HaloTag7 in cell-based assays[1]. IC50 & Target:E3 Ligase Ligand-Linker Conjugate[1] In Vitro: (S,R,S)-AHPC-PEG2-C4-Cl uses the VHL ligand[1]. The linkers contain a mixture of hydrophobic and hydrophilic moieties to balance the hydrophobicity/hydrophilicity of the resulting hybrid compounds. PROTACs that induce the degradation of an oncogenic tyrosine kinase, BCR-ABL has been developed. (S,R,S)-AHPC-PEG2-C4-Cl can be attached to potent TKIs (bosutinib and dasatinib) that mediate the degradation of c-ABL and BCR-ABL by hijacking either CRBN or VHL E3 ubiquitin ligase[2].
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