Apicidin
CAS No. : 183506-66-3
(Synonyms: OSI 2040)
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|---|---|---|
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| 5mg | $320 | In-stock |
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| Cat. No. : | HY-N6735 |
| M.Wt: | 623.78 |
| Formula: | C34H49N5O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
Apicidin (OSI 2040) is a fungal metabolite, acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor, with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research[1][2][3][4].
IC50 & Target:HDAC[1]
In Vitro:Apicidin inhibits mammalian (HeLa) cell proliferation in vitro (50% inhibitory concentrations, 50-100 nM)[2].
Apicidin (0.1-10 μM, 24 h) inhibits the growth and the expression of HDAC in AT-84 cells dose-dependently[4].
Apicidin (1, 5 μM, 24 h) induces apoptosis and autophagy in AT-84 cells dose-dependently[4].
In Vivo:Apicidin (5 mg/kg, i.p., daily for 14 d) inhibits tumor growth up to 47% relative to the control group and exerts no significant systemic toxicity, including body weight changes or other apparent adverse effects[4].
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