Gemcabene
CAS No. : 183293-82-5
(Synonyms: PD-72953)
| Size | Price | Stock |
|---|---|---|
| 5mg | $75 | In-stock |
| 10mg | $125 | In-stock |
| 25mg | $275 | In-stock |
| 50mg | $465 | In-stock |
| 100mg | $795 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-109567 |
| M.Wt: | 302.41 |
| Formula: | C16H30O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
Gemcabene (PD-72953), a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) and lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP), exerting anti-inflammatory activity[1][2][3]. In Vitro: Gemcabene calcium (PD-72953 calcium) significantly downregulates hepatic mRNA markers of inflammation (TNF-α, MCP-1, MIP-1β, CCR5, CCR2, NF-κB), lipogenesis and lipid modulation (ApoC-III, ACC1, ADH-4, Sulf-2), and fibrosis (TIMP-1 and MMP-2)[3].
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