RA839
CAS No. : 1832713-02-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $180 | In-stock |
| 10mg | $240 | In-stock |
| 25mg | $390 | In-stock |
| 50mg | $585 | In-stock |
| 100mg | $875 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-110275 |
| M.Wt: | 452.57 |
| Formula: | C25H28N2O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
RA839 is a selective Nrf2/ARE pathway agonist and non-covalent small molecule binder of Keap1 (Kd is approximately 6 μM). RA839 prevents inducible nitric oxide synthase expression and nitric oxide release. RA839 exerts anti-rotaviral and anti-inflammatory effects[1][2].
In Vitro:RA839 (5-20 μM) reduces LPS-induced NO release in BMDM in a concentration-dependent manner[1].
RA839 (5-40 μM) shows potent anti-rotaviral efficacy in RV-SA11 infected (12 hpi) MA104 cells, with reducing RV RNA and protein expressions, viroplasm formation[2].
In Vivo:RA839 (30 mg/kg, i.p.) modulates Nrf2 target genes in the context of reduced oxidative liver metabolism in mice, inducing hepatic mRNA levels of the prototypic Nrf2 target genes GCLC and NQO1[1].
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