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SRI 31215 (TFA)


CAS No. : 1832686-44-8

1832686-44-8
Price and Availability of CAS No. : 1832686-44-8
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5mg $180 In-stock
10mg $280 In-stock
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100mg $1600 In-stock
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Cat. No. : HY-114363A
M.Wt: 533.59
Formula: C27H34F3N5O3
Purity: >98 %
Solubility: DMSO : 125 mg/mL (ultrasonic)
Introduction of 1832686-44-8 :

SRI 31215 (TFA) is a Matriptase/Hepsin/hepatocyte growth factor activator (HGFA) triplex inhibitor and mimics the activity of HAI-1/2 (endogenous inhibitors of HGF activation). SRI 31215 has potent inhibitory activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively. SRI 31215 can be used for the research of cancer[1]. IC50 & Target:IC50: 0.69 μM (matriptase); 0.65 μM (hepsin); 0.30 μM (HGFA)[1] In Vitro:SRI 31215 (TFA) has potent activity against matriptase, hepsin and HGFA with IC50 values of 0.69 μM, 0.65 μM and 0.30 μM, respectively[1].
SRI 31215 (10 μM) inhibits the proteolytic activation of pro-HGF[1].
SRI 31215 (10 μM, 30 min) inhibits fibroblast-induced HGF/MET signaling in tumor cells[1].
SRI 31215 (10 μM, 24 h) inhibits fibroblast-induced epithelial mesenchymal transition (EMT) and migration in tumor cells[1].
SRI 31215 (10 μM) overcomes the resistance to EGFR inhibitors mediated by autocrine HGF/MET signaling in colon cancer cells[1].
SRI31215 (10 μM, 72 h) averts fibroblast-mediated resistance to EGFRi-induced apoptosis[1].

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