DDP-38003 (dihydrochloride)
CAS No. : 1831167-98-6
| Size | Price | Stock |
|---|---|---|
| 5mg | $170 | In-stock |
| 10mg | $290 | In-stock |
| 50mg | $1100 | In-stock |
| 100mg | $1900 | In-stock |
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| Cat. No. : | HY-19612A |
| M.Wt: | 423.38 |
| Formula: | C21H28Cl2N4O |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 29 mg/mL |
DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM[1]. IC50 & Target:IC50: 84 nM (KDM1A/LSD1)[1] In Vitro:DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue[1]. In Vivo:DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent[1].
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